Ankylosing Spondylitis is associated with enthesitis at multiple sites. It is the commonest inflammatory polyenthesitis of the spine. It has a predisposition to involve entheses of the spine from the low back where it most typically starts ....
Although AS typically starts in the low back it can start at other sites throughout the body. This page explains why that is the case and is especially important ....
The sacroiliac joints links the spine to the pelvis and is a major cause of back pain and especially pain in the low back. The sacroiliac joint is lined by synovium and produces lubricating synovial fluid ...
Ankylosing spondylitis (AS) typically starts with low back pain in the sacroiliac joint. This page helps explain why ankylosing spondylitis starts in the sacroiliac joint ....
The chest wall is an incredibly complex region with multiple insertion points that may become inflamed in Ankylosing Spondylitis and related disorders. The purpose of this page is to explain to both patients and doctors why chest wall enthesitis is frequently not recognised ....
Acute anterior uveitis causes pain, redness and loss of vision due to inflammation in the anterior part of the eye. Acute anterior uveitis is associated with the inflammatory diseases collectively known as the seronegative spondyloarthropathies (SpA). These arthritic conditions ....
Bone erosion is a process whereby the surface of a bone (the bone cortex) is degraded or eroded and is most typically seen in the setting of inflammation. In this context specialised cells termed osteoclasts ....
New bone formation is the major cause of permanent disability in Ankylosing Spondylitis (AS). Although new bone formation occurs both in the peripheral and axial (spinal) skeleton, it is the spinal involvement that is ....
The aorta is the major blood vessel that is attached to the heart. At the root or point of attachment to the heart, there is a specialised structure called the aortic valve. The Seronegative Spondyloarthropathies and Ankylosing Spondylitis ....
Gut inflammation typically is associated with joint pain and swelling. There is increasing evidence that the major site of involvement in the joints in the arthritis associated with Ulcerative Colitis ....
Fortunately disease of the lung itself that causes significant damage that leads to shortness of breath is uncommon in Ankylosing Spondylitis (AS). The major way in which AS causes breathlessness ....
After sacroiliac and spinal involvement the next most common joints to be afflicted in AS are the large joints including the hips. Hip disease can be difficult to recognise because the joint is located deep .....
Shoulder joint involvement is a common features of AS but it does not generally cause the same degree of disability as spine or hip involvement. The medical knowledge relating .....
Patients with AS may experience easily recognised types of enthesitis of the foot. These most typically include Achilles Enthesitis and Plantar fasciitis. The foot and ankle are also sites of ....
The role of movement and the forces generated by walking, running and other activities and the ability of strenuous exercise to cause tissue damage that might trigger AS is a new area of research. The role of mechanical factors ....
The major cause of disability in long standing Ankylosing Spondylitis (AS) is spinal inflammation that may result in subsequent new bone formation. This page explains spinal inflammation in AS that is largely linked to enthesitis ....
From having no proven therapies, with the possible exception of non-steroidal anti-inflammatory drugs which are of limited value, the treatment of the spinal polyenthesitis and associated osteitis (bone inflammation) ....
A major feature of Ankylosing Spondylitis (AS) is deep seated buttock pain that flips from side to side. Frustratingly, when the doctors examine a patient with such pain, there may be nothing to find .....
This page explains the mechanical model for Ankylosing Spondylitis and the related Spondyloarthropathies. This scientific theory was published at the turn of the millennium and is explained here in terminology for the non-expert ....
Ankylosing Spondylitis (AS) localises to sites of high mechanical stressing at entheses and the bone adjacent to fibrocartilage at sites including the sacroiliac joint. Research in man into enthesitis and animal model data increasingly supports ....
Although the HLA-B27 gene is associated with the severity of bone inflammation in the sacroiliac joints, it is intriguing to note that it does not automatically tally with spinal inflammation which appears to be key for disease progression ....
Historically it took up to a decade, or longer for a diagnosis of Ankylosing Spondylitis (AS) to be made. The reason for this was that the diagnostic changes evident on sacroiliac joint X-rays were slow to develop ....
Osteitis means bone inflammation. The pain from sacroiliitis in Ankylosing Spondylitis (AS) is often due to osteitis. However, osteitis can occur at multiple other sites in AS. This page explains the importance of osteitis ....
Patients with symptoms that are classical of Ankylosing Spondylitis (AS) may have a normal MRI scan that is "not showing any inflammation". This is despite the fact that an X-ray may have previously shown sacroiliitis ....
Because Ankylosing Spondylitis (AS) has a tendency to start in the sacroiliac joint and because the initial inflammatory lesion may be located underneath the shock absorbing fibrocartilage, people have failed to realise the immense ....
DISH is a chronic age related condition, with characteristic new bone growth at the entheses. DISH represents the best example of enthesogenic osteoarthritis - a type of osteoarthritis that is exclusively related to the enthesis ....
This page explains the role of the HLA-B27 gene in Ankylosing Spondylitis in relationship to the primary sites of skeletal disease at the enthesis and related sites sites of high mechanical stressing including the sacroiliac joint bone ....
Historically it was thought that inflammation that was not due to tissue infection was "inflammation against self" or autoimmunity. Hundreds of diseases, including Ankylosing spondylitis (AS) were called autoimmune ....
The Spondyloarthopathy concept was first described in Leeds in the early 1970s. The description was based on the fact that certain diseases occurred together in the same patient or certain diseases ran in some families ....